2020.08.26 Our recent work was accepted by Journal of Materials Science & Technology

Published On：2020-08-31 Functionalization of mesoporous silica spheres with well-dispersed and ultra-small nanodots to exert their synergistic effects for biomedical applications has been considered to be an urgent challenge. Herein, homogeneously incorporation of ultra-small and monodispersed MoS2 nanodots in the mesoporous silica nanospheres (MSN) was achieved by a facile one-step solvothermal reaction. The as-synthesized UsMSND@MSN possessed uniform size (～115?nm) and favorable biocompatibility inherited from MSN. The dispersed UsMSND within MS could act as anchoring sites for aromatic anti-cancer drug DOX loading, and consequently achieved pH-responsive release based on the special π-π/electrostatic interactions with the DOX molecules. More importantly, the well-dispersed UsMSND in MSN could function as the non-toxic contrast agent for the sensitive in vivo CT imaging in various tumors including breast cancer and glioma with different sections. This work promises a good strategy for dispersed incorporation of UsMSND into MSN as an excellent pH-responsive platform for simultaneous cancer imaging and therapy. This work was mainly accomplished by Leilei Chen and Min Qian(https://www.sciencedirect.com/science/article/abs/pii/S100503022030267X).