2020.08.26 Our recent work was accepted by Biomaterials

In this work, hollow covalent organic framework (COF) nanospheres with high crystallinity and uniformed sizes were facilely prepared via heterogeneous nucleation-growth. The prepared COF had large surface area/pore volume and exhibited appropriate degradation behavior under acid environment, where therefore doxorubicin was effectively encapsulated and exhibited a pH-sensitive release. Most charmingly, T10 peptide that has high affinity with transferrin (Tf), was conjugated to endow the hollow COF nanospheres interesting properties to specifically absorb endogenous Tf in vivo as Tf corona. For the first time, multifunctional hollow COF nanospheres (the better one named DCPT-2) were successfully synthesized to achieve interference-free cascade-targeting glioma drug delivery across the blood-brain barrier. Treatment with DCPT-2 brought an improved therapeutic outcome with significantly prolonged median survival time and low side effects for orthotopic glioma-bearing mice. This work promised not only a potential protein corona-mediated COF-based drug delivery platform with good biocompatibility for effective and precise brain tumor therapy, but also a protein corona-mediated targeting strategy for general cancer therapy. This work was mainly accomplished by Taotao Huo (https://www.sciencedirect.com/science/article/pii/S0142961220305512).