2019.11.7 Our recent work on “Biodegradable Mesoporous Silica Achieved via Carbon Nanodots-Incorporated Framework Swelling for Debris-mediated Photothermal Synergistic Immunotherapy” was accepted by Nano Letters.

In this work, we have prepared biodegradable mesoporous silica with carbon nanodots-incorporated in framework (CD@MSN). the obtained CD@MSN were not only biodegradable via the framework-incorporated CD-induced swelling, but also capable of gathering dispersive CD with enhanced photothermal effect and elevated targeting accumulation, which therefore can achieve photothermal imaging-guided photothermal therapy (PTT) in vitro and in vivo. Besides, it was found that CD@MSN-mediated PTT can synergistically achieve immune-mediated inhibition of tumor metastasis via stimulating the proliferation and activation of NK cells and macrophages, and simultaneously up-regulating the secretion of corresponding cytokines (IFN-γ and Granzyme B). This work proposed an unusual synthesis of biodegradable mesoporous silica and provided an innovative insight into the biodegradable nanoparticles-associated anticancer immunity. This work was mainly accomplished by Min Qian who is the first author of the paper.